Church Fathers Call Rome Babylon

 Irenaeus (c. 130–202 AD) – Against Heresies

“The legs of iron are the Romans, among whom is partition of the kingdom, for the kingdom is divided, and yet the iron rules.” — Against Heresies V.26.1
“In the last times, a kingdom shall arise, more fierce than any before it… this is plainly the empire which now rules, the iron kingdom which Daniel saw.” — Against Heresies V.26.2
“The fourth kingdom which Daniel foresaw is plainly the Roman Empire, which still exists, and which the Revelator calls Babylon.” — Against Heresies V.30.3

Tertullian (c. 155–240 AD) – Against Marcion / On the Resurrection of the Flesh

“In the fourth kingdom, which is that of the Romans, the iron legs are strong; thus the empire which now holds the world is signified.” — Against Marcion V.16
“We Christians are under no delusion; we know that the empire must be crushed and divided, as Daniel foresaw in the image of iron and clay.” — On the Resurrection of the Flesh 24
“Babylon in the Apocalypse is none other than the great city ruling over the kings of the earth—this can only be Rome.” — Against Marcion III.13

Lactantius (c. 250–325 AD) – Divine Institutes

“The fourth kingdom is that of the Romans, which, having subdued all nations, possesses the world itself. This is the iron which broke in pieces and bruised all things.” — Divine Institutes VII.15
“Rome is that Babylon which the Apocalypse of John foretells shall fall, because she made all nations drink of her fornications.” — Divine Institutes VII.25
“As the iron is strong, so the Roman empire is most mighty; yet it is mingled with clay, for it is divided and cannot stand.” — Divine Institutes VII.16

Jerome (c. 347–420 AD) – Commentary on Daniel

“The fourth kingdom, which clearly refers to the Romans, is the iron which breaks in pieces and overcomes all things.” — Commentary on Daniel II.40
“Babylon is a figure of Rome, which in John’s Apocalypse is called the harlot seated upon seven hills.” — Commentary on Daniel VII.7
“The city which rules over the whole world is none other than Rome; therefore, John rightly called her Babylon, signifying her confusion and idolatry.” — Commentary on Daniel VII.25